Michael J Fox is returning to the small screen in a new TV series - more than a decade after he left to concentrate on fighting Parkinson's disease.
His new comedy series, based loosely on his personal life, has a 22-episode commitment from US network NBC and is set to premiere in autumn 2013.
Fox said: "I'm extremely pleased to be back at NBC with a great creative team and a great show."
The single-camera comedy will feature Fox as a husband and father-of-three from New York City who is dealing with family, career and challenges which include Parkinson's, the network announced.
"To bring Michael J Fox back to NBC is a supreme honour and we are thrilled that one of the great comedic television stars is coming home again," said Robert Greenblatt, chairman of NBC Entertainment. He called Fox "utterly relatable, optimistic and in a class by himself".
Fox first won stardom for his work as Alex Keaton on the hit comedy Family Ties, which began its seven-season run on NBC in 1982.
The 51-year-old actor was diagnosed with Parkinson's disease in 1991. In 2000, he left his ABC comedy Spin City after four seasons, saying he intended to focus on helping find a cure for the disease.
He founded the Michael J. Fox Foundation, which is dedicated to finding a cure for sufferers of Parkinson's disease while promoting the development of improved therapies and raising public awareness of the disease.
Since then, he limited his acting appearances to guest shots on series including Rescue Me, Boston Legal, Curb Your Enthusiasm and The Good Wife. But in May, he told ABC News that a new drug regimen has helped him control the tics that are a result of the disease and could allow him to take on more acting roles.
His feature films include the Back to the Future trilogy, Teen Wolf, Bright Lights, Big City and Casualties of War. He has won five Emmy awards.