Mexican authorities said 11 people died after a bus plunged into a ravine while heading to the Pacific resort of Mazatlan.
Durango state government Secretary Jaime Fernandez Saracho said the bus fell about 150 feet from a mountainous road known as the Devil's Backbone.
Twenty-two other passengers were injured.
Fernandez said Friday's early morning accident could have been caused by fog and the driver not knowing the road.
He said the victims were mostly senior citizens, although one was a 13-year-old boy.
The rescue took hours in rough terrain. Many of the injured were flown by helicopter to Durango and Mazatlan hospitals.
The accident came four weeks to the day after a bus fell off a cliff in Nayarit state, killing 24 people.